Is it possible to use Jest with multiple presets at the same time?

Presets are just plain Javascript objects, so in many circumstances you may simply merge them. For example, that’s how I’m enabling ts-jest and jest-puppeteer simultaneously:

const merge = require('merge')
const ts_preset = require('ts-jest/jest-preset')
const puppeteer_preset = require('jest-puppeteer/jest-preset')

module.exports = merge.recursive(ts_preset, puppeteer_preset, {
    globals: {
        test_url: `http://${process.env.HOST || '127.0.0.1'}:${process.env.PORT || 3000}`,
    },
})

If there are certain options that can’t be ‘merged’ like that, just handle these cases manually.