While debugging System.Diagnostics.Debug.WriteLine will display in the output window (Ctrl+Alt+O), you can also add a TraceListener to the Debug.Listeners collection to specify Debug.WriteLine calls to output in other locations.
Note: Debug.WriteLine calls may not display in the output window if you have the Visual Studio option “Redirect all Output Window text to the Immediate Window” checked under the menu Tools → Options → Debugging → General. To display “Tools → Options → Debugging“, check the box next to “Tools → Options → Show All Settings“.