Should C++ function default argument values be specified in headers or .cpp source files?

You make the declaration (i.e. in the header file – functions.h) contain the optional parameter, not the definition (functions.cpp).

//functions.h
extern void apply_surface(int, int, SDL_Surface *, SDL_Surface *,SDL_Rect * clip = NULL);

//functions.cpp
void apply_surface(int x, int y, SDL_Surface * source, SDL_Surface *
destination,SDL_Rect *clip /*= NULL*/)
{
    ...
}