from django.core.files import File
user1=User(name="abc")
user1.pic.save('abc.png', File(open('/tmp/pic.png', 'r')))
You will end up with the image abc.png copied into the upload_to directory
specified in the ImageField.
In this case, the user1.pic.save method will also save the user1 instance.
The documentation for saving an ImageField can be found here https://docs.djangoproject.com/en/dev/ref/files/file/