Python best way to remove char from string by index [duplicate]

You can bypass all the list operations with slicing:

S = S[:1] + S[2:]

or more generally

S = S[:Index] + S[Index + 1:]

Many answers to your question (including ones like this) can be found here: How to delete a character from a string using python?. However, that question is nominally about deleting by value, not by index.