large graph visualization with python and networkx

 from matplotlib import pylab
 import networkx as nx

 def save_graph(graph,file_name):
    #initialze Figure
    plt.figure(num=None, figsize=(20, 20), dpi=80)
    plt.axis('off')
    fig = plt.figure(1)
    pos = nx.spring_layout(graph)
    nx.draw_networkx_nodes(graph,pos)
    nx.draw_networkx_edges(graph,pos)
    nx.draw_networkx_labels(graph,pos)

    cut = 1.00
    xmax = cut * max(xx for xx, yy in pos.values())
    ymax = cut * max(yy for xx, yy in pos.values())
    plt.xlim(0, xmax)
    plt.ylim(0, ymax)

    plt.savefig(file_name,bbox_inches="tight")
    pylab.close()
    del fig

#Assuming that the graph g has nodes and edges entered
save_graph(g,"my_graph.pdf")

#it can also be saved in .svg, .png. or .ps formats

This answers your first issue.
Networkx does not have the facility to zoom into nodes. Use Gephi for this functionality.
Gephi accepts an edge list in CSV format and produces a visualization, where zooming can be done interactively.