Is there any difference between using ABC vs ABCMeta?

abc.ABC basically just an extra layer over metaclass=abc.ABCMeta. i.e abc.ABC implicitly defines the metaclass for us.

(Source: https://hg.python.org/cpython/file/3.4/Lib/abc.py#l234)

class ABC(metaclass=ABCMeta):
    """Helper class that provides a standard way to create an ABC using
    inheritance.
    """
    pass

The only difference is that in the former case you need a simple inheritance and in the latter you need to specify the metaclass.

From What’s new in Python 3.4(emphasis mine):

New class ABC has ABCMeta as its meta class. Using ABC as a base
class has essentially the same effect as specifying
metaclass=abc.ABCMeta, but is simpler to type and easier to read.

Related issue: Create abstract base classes by inheritance rather than a direct invocation of __metaclass__