No, as mentioned a Tuple<> is intended to be immutable.
I use a custom Pair class if I need a mutable type that does the same thing, although in the spirit of embracing function concepts, I try not to use it.
namespace StackOverflow.Helpers
{
public class Pair<T1, T2>
{
public T1 First { get; set; }
public T2 Second { get; set; }
}
}