Is it possible to set a different specification per cache using caffeine in spring boot?

This is your only chance:

@Bean
public CaffeineCache cacheA() {
    return new CaffeineCache("CACHE_A",
            Caffeine.newBuilder()
                    .expireAfterAccess(1, TimeUnit.DAYS)
                    .build());
}

@Bean
public CaffeineCache cacheB() {
    return new CaffeineCache("CACHE_B",
            Caffeine.newBuilder()
                    .expireAfterWrite(7, TimeUnit.DAYS)
                    .recordStats()
                    .build());
}

Just expose your custom caches as beans. They are automatically added to the CaffeineCacheManager.