Please install http://asepsis.binaryage.com/ and then reboot your mac.
ASEPSIS redirect all .DS_Store on your mac to /usr/local/.dscage
After that, You could recursively delete all .DS_Store from your Mac.
find ~ -name ".DS_Store" -delete
or
find <your path> -name ".DS_Store" -delete
You should repeat procedure after each major Mac update.