You can simply create splitter containing items in Qt Designer :
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First place your widgets on your dialog or widget in designer (They should not be in a layout)
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Select the widgets that you want to be in a splitter (By holding CTL and clicking on them)
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Right click on a selected widget and from Layout menu select Lay Out Horizontally in Splitter or Lay Out Vertically in Splitter.
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Now apply a grid layout to the dialog and everything should be OK. You would see something like this in Object Inspector View :
