How can I produce a human readable difference when subtracting two UNIX timestamps using Python?

You can use the wonderful dateutil module and its relativedelta class:

import datetime
import dateutil.relativedelta

dt1 = datetime.datetime.fromtimestamp(123456789) # 1973-11-29 22:33:09
dt2 = datetime.datetime.fromtimestamp(234567890) # 1977-06-07 23:44:50
rd = dateutil.relativedelta.relativedelta (dt2, dt1)

print "%d years, %d months, %d days, %d hours, %d minutes and %d seconds" % (rd.years, rd.months, rd.days, rd.hours, rd.minutes, rd.seconds)
# 3 years, 6 months, 9 days, 1 hours, 11 minutes and 41 seconds

It doesn’t count weeks, but that shouldn’t be too hard to add.