fib = lambda n:reduce(lambda x,n:[x[1],x[0]+x[1]], range(n),[0,1])[0]
(this maintains a tuple mapped from [a,b] to [b,a+b], initialized to [0,1], iterated N times, then takes the first tuple element)
>>> fib(1000)
43466557686937456435688527675040625802564660517371780402481729089536555417949051
89040387984007925516929592259308032263477520968962323987332247116164299644090653
3187938298969649928516003704476137795166849228875L
(note that in this numbering, fib(0) = 0, fib(1) = 1, fib(2) = 1, fib(3) = 2, etc.)
(also note: reduce is a builtin in Python 2.7 but not in Python 3; you’d need to execute from functools import reduce in Python 3.)