Dynamically toggle visibility of WPF grid column from C# code

<ColumnDefinition>
  <ColumnDefinition.Style>
    <Style TargetType="ColumnDefinition">
      <Setter Property="Width" Value="*" />
        <Style.Triggers>
          <DataTrigger Binding="{Binding IsColumnVisible}" Value="False">
            <Setter Property="Width" Value="0" />
          </DataTrigger>
        </Style.Triggers>
    </Style>
  </ColumnDefinition.Style>
</ColumnDefinition>

Please do implement INotifyPropertyChanged in your ViewModel