To run multiple commands in docker, use /bin/bash -c and semicolon ;
docker run image_name /bin/bash -c "cd /path/to/somewhere; python a.py"
In case we need command2 (python) will be executed if and only if command1 (cd) returned zero (no error) exit status, use && instead of ;
docker run image_name /bin/bash -c "cd /path/to/somewhere && python a.py"