Control formatting of the argparse help argument list?

You could supply formatter_class argument:

parser = argparse.ArgumentParser(prog='tool',
  formatter_class=lambda prog: argparse.HelpFormatter(prog,max_help_position=27))

args = [('-u', '--upf', 'ref. upf', dict(required='True')),
        ('-s', '--skew', 'ref. skew', {}),
        ('-m', '--model', 'ref. model', {})]
for args1, args2, desc, options in args:  
     parser.add_argument(args1, args2, help=desc, **options)

parser.print_help()

Note: Implementation of argparse.HelpFormatter is private only the name is public. Therefore the code might stop working in future versions of argparse. File a feature request to provide a public interface for the customization of max_help_position on http://bugs.python.org/

Output

usage: tool [-h] -u UPF [-s SKEW] [-m MODEL]

optional arguments:
  -h, --help               show this help message and exit
  -u UPF, --upf UPF        ref. upf
  -s SKEW, --skew SKEW     ref. skew
  -m MODEL, --model MODEL  ref. model