As far as I know, the only way to do this is to get all interfaces and see if the generic definition matches the required interface type.
bool result1 = type.GetInterfaces()
.Where(i => i.IsGenericType)
.Select(i => i.GetGenericTypeDefinition())
.Contains(typeof(MyInterface<,>));
EDIT: As Jon points out in the comments, you could also do:
bool result1 = type.GetInterfaces()
.Where(i => i.IsGenericType)
.Any(i => i.GetGenericTypeDefinition() == typeof(MyInterface<,>));