list to dictionary conversion with multiple values per key?

from collections import defaultdict

d1 = defaultdict(list)

for k, v in l:
    d1[k].append(v)

d = dict((k, tuple(v)) for k, v in d1.items())

d contains now {1: ('A', 'B'), 2: ('C',)}

d1 is a temporary defaultdict with lists as values, which will be converted to tuples in the last line. This way you are appending to lists and not recreating tuples in the main loop.