MacPorts is the way to go.
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Like @user475443 pointed, MacPorts has many many more packages. With brew you’ll find yourself trapped soon because the formula you need doesn’t exist.
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MacPorts is a native application: C + TCL. You don’t need Ruby at all. To install Ruby on Mac OS X you might need MacPorts, so just go with MacPorts and you’ll be happy.
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MacPorts is really stable, in 8 years I never had a problem with it, and my entire Unix ecosystem relay on it.
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If you are a PHP developer you can install the last version of Apache (Mac OS X uses 2.2), PHP and all the extensions you need, then upgrade all with one command. Forget to do the same with Homebrew.
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MacPorts support groups.
foo@macpro:~/ port select --summary Name Selected Options ==== ======== ======= db none db46 none gcc none gcc42 llvm-gcc42 mp-gcc48 none llvm none mp-llvm-3.3 none mysql mysql56 mysql56 none php php55 php55 php56 none postgresql postgresql94 postgresql93 postgresql94 none python none python24 python25-apple python26-apple python27 python27-apple noneIf you have both PHP55 and PHP56 installed (with many different extensions), you can swap between them with just one command. All the relative extensions are part of the group and they will be activated within the chosen group: php55 or php56. I’m not sure Homebrew has this feature.
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Rubists like to rewrite everything in Ruby, because the only thing they are at ease is Ruby itself.