What does the argument mean in fig.add_subplot(111)?

I think this would be best explained by the following picture:

To initialize the above, one would type:

import matplotlib.pyplot as plt
fig = plt.figure()
fig.add_subplot(221)   #top left
fig.add_subplot(222)   #top right
fig.add_subplot(223)   #bottom left
fig.add_subplot(224)   #bottom right 
plt.show()