You should use http module:
var http = require('http');
var express = require('express'),
app = module.exports.app = express();
var server = http.createServer(app);
var io = require('socket.io').listen(server); //pass a http.Server instance
server.listen(80); //listen on port 80
//now you can use app and io
More details you can find in a documentation: http://socket.io/docs/#using-with-express-3/4