Simplest way to throw an error/exception with a custom message in Swift?

The simplest approach is probably to define one custom enum with just one case that has a String attached to it:

enum MyError: ErrorType {
    case runtimeError(String)
}

Or, as of Swift 4:

enum MyError: Error {
    case runtimeError(String)
}

Example usage would be something like:

func someFunction() throws {
    throw MyError.runtimeError("some message")
}
do {
    try someFunction()
} catch MyError.runtimeError(let errorMessage) {
    print(errorMessage)
}

If you wish to use existing Error types, the most general one would be an NSError, and you could make a factory method to create and throw one with a custom message.