Bit of awk should do it?
awk '{s+=$1} END {print s}' mydatafile
Note: some versions of awk have some odd behaviours if you are going to be adding anything exceeding 2^31 (2147483647). See comments for more background. One suggestion is to use printf
rather than print
:
awk '{s+=$1} END {printf "%.0f", s}' mydatafile