If you want to replace index 2, then
list.updated(2,5) // Gives 1 :: 2 :: 5 :: 4 :: Nil
If you want to find every place where there’s a 2 and put a 5 in instead,
list.map { case 2 => 5; case x => x } // 1 :: 5 :: 3 :: 4 :: Nil
In both cases, you’re not really “replacing”, you’re returning a new list that has a different element(s) at that (those) position(s).