Regular Expression: Allow letters, numbers, and spaces (with at least one letter or number)

You simply need to specify your current RE, followed by a letter/number followed by your current RE again:

^[A-Z0-9 _]*[A-Z0-9][A-Z0-9 _]*$

Since you’ve now stated they’re Javascript REs, there’s a useful site here where you can test the RE against input data.

If you want lowercase letters as well:

^[A-Za-z0-9 _]*[A-Za-z0-9][A-Za-z0-9 _]*$