Reference assemblies should not be loaded for execution

Try delete that section from your web.config

<dependentAssembly>
    <assemblyIdentity name="System.Runtime" publicKeyToken="b03f5f7f11d50a3a" culture="neutral" />
    <bindingRedirect oldVersion="0.0.0.0-4.0.10.0" newVersion="4.0.10.0" />
</dependentAssembly>