Should be something like this:
@Html.CheckBoxFor(m => m.IsPublished, new { @disabled = "disabled" })
UPDATE:
Assuming that your class AdvSlot contains a property IsPublished you can write in your loop:
<td>
@Html.CheckBox(item.AdvSlotId + "_IsPublished", item.IsPublished, new { @disabled = "disabled" });
</td>