Python type hinting: how to tell X is a subclass for Foo?

It seems like other current (22 Sep 2016) answers here are incorrect. According to PEP 484 (about Type Hints), there exists a hint for type of class objects, called Type[C]. And according to typing module’s documentation, you can use typing.Type[C] to achieve exactly what you want. I’m using those myself with Python 3.5.2.

Quoting the PEP:

Sometimes you want to talk about class objects, in particular class objects that inherit from a given class. This can be spelled as Type[C] where C is a class. To clarify: while C (when used as an annotation) refers to instances of class C , Type[C] refers to subclasses of C .

And quoting the docs:

A variable annotated with C may accept a value of type C. In contrast, a variable annotated with Type[C] may accept values that are classes themselves – specifically, it will accept the class object of C.

And referring to your specific example:

import typing

class A(object):
    pass

class B(A):
    pass

def register(cls: typing.Type[A]):
    assert issubclass(cls, A)

register(A)
register(B)

You can check such code statically using mypy, and it should work in simple cases — beware however that mypy is a work in progress, as of now there are several issues open about Type[C] hinting.