I asked a similar question here:

How do I upload a file with metadata using a REST web service?

You basically have three choices:

  1. Base64 encode the file, at the expense of increasing the data size by around 33%, and add processing overhead in both the server and the client for encoding/decoding.
  2. Send the file first in a multipart/form-data POST, and return an ID to the client. The client then sends the metadata with the ID, and the server re-associates the file and the metadata.
  3. Send the metadata first, and return an ID to the client. The client then sends the file with the ID, and the server re-associates the file and the metadata.