Yes, you can link to specific pages by number or named locations and that will always work if the user’s browser uses Adobe Reader as plugin for viewing PDF files.
For a specific page by number:
<a href="http://www.domain.com/file.pdf#page=3">Link text</a>
For a named location (destination):
<a href="http://www.domain.com/file.pdf#nameddest=TOC">Link text</a>
To create destinations within a PDF with Acrobat:
- Manually navigate through the PDF for the desired location
- Go to View > Navigation Tabs > Destinations
- Under Options, choose Scan Document
- Once this is completed, select New Destination from the Options menu and enter an appropriate name