You already have what you need, with a minor syntax change:
<a href="www.mysite.com" onclick="return theFunction();">Item</a>
<script type="text/javascript">
function theFunction () {
// return true or false, depending on whether you want to allow the `href` property to follow through or not
}
</script>
The default behavior of the <a> tag’s onclick and href properties is to execute the onclick, then follow the href as long as the onclick doesn’t return false, canceling the event (or the event hasn’t been prevented)