Httpclient This instance has already started one or more requests. Properties can only be modified before sending the first request

HttpClient.DefaultRequestHeaders (and BaseAddress) should only be set once, before you make any requests. HttpClient is only safe to use as a singleton if you don’t modify it once it’s in use.

Rather than setting DefaultRequestHeaders, set the headers on each HttpRequestMessage you are sending.

var request = new HttpRequestMessage(HttpMethod.Post, url);
request.Headers.Accept.Clear();
request.Headers.Accept.Add(new MediaTypeWithQualityHeaderValue("application/json"));
request.Headers.Authorization = new AuthenticationHeaderValue("Bearer", token);
request.Content = new StringContent("{...}", Encoding.UTF8, "application/json");
var response = await _client.SendAsync(request, CancellationToken.None);

Replace "{...}" with your JSON.