It’s tempting to mess with __dict__, but that won’t apply to attributes inherited from a parent class.
You can either iterate over the dict to assign to the object:
for (key, value) in my_data_dict.items():
setattr(obj, key, value)
obj.save()
Or you can directly modify it from a queryset (making sure your query set only returns the object you’re interested in):
FooModel.objects.filter(whatever="anything").update(**my_data_dict)