Try this function:
Create Function [dbo].[RemoveNonAlphaCharacters](@Temp VarChar(1000))
Returns VarChar(1000)
AS
Begin
Declare @KeepValues as varchar(50)
Set @KeepValues="%[^a-z]%"
While PatIndex(@KeepValues, @Temp) > 0
Set @Temp = Stuff(@Temp, PatIndex(@KeepValues, @Temp), 1, '')
Return @Temp
End
Call it like this:
Select dbo.RemoveNonAlphaCharacters('abc1234def5678ghi90jkl')
Once you understand the code, you should see that it is relatively simple to change it to remove other characters, too. You could even make this dynamic enough to pass in your search pattern.