Since Laravel uses config files to access and store .env data, you can set this data on the fly with config() method:
config(['database.connections.mysql.host' => '127.0.0.1']);
To get this data use config():
config('database.connections.mysql.host')
To set configuration values at runtime, pass an array to the
confighelper
https://laravel.com/docs/5.3/configuration#accessing-configuration-values