How to prevent firing CheckedChanged event when checking a control programmatically?

I think your way is fine.

The other way to do it is remove the EventHandler before the check, and then add it back again after the check. This way eliminates the need for the isFrozen variable.

private void btn1_CheckedChanged(object sender, EventArgs e)
  btn2.CheckedChanged -= btn2_CheckedChanged;
  btn2.Checked = false;
  btn2.CheckedChanged += btn2_CheckedChanged;

    // Do some staff

private void btn2_CheckedChanged(object sender, EventArgs e)
  btn1.CheckedChanged -= btn1_CheckedChanged;
  btn1.Checked = false;
  btn1.CheckedChanged += btn1_CheckedChanged;

    // Do another staff

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