After placing it, say myplugin.el to your ~/.emacs.d/ directory, add the following in your .emacs file:
(add-to-list 'load-path "~/.emacs.d/")
(load "myplugin.el")
Also, in many cases you would need the following instead of the second line:
(require 'myplugin)
In any case, you should consult the documentation of the package you are trying to install on which one you should use.
If you are unsure where your ~ directory is, you may see it by typing C-x d ~/ and pressing Enter.