You can add this to your Web.Config:
<system.webServer>
<httpProtocol>
<customHeaders>
<remove name="X-Powered-By" />
</customHeaders>
</httpProtocol>
</system.webServer>
Update: if you’re using the MVC framework I would also recommend removing the X-AspNetMvc-Version and X-AspNet-Version headers as well. This is accomplished by setting MvcHandler.DisableMvcResponseHeader = true in your Global.asax file and <system.web><httpRuntime enableVersionHeader="false" /></system.web> in your Web.config respectively.