A function can have multiple signatures if the signatures differ in arity. You can use that to supply default values.
(defn string->integer
([s] (string->integer s 10))
([s base] (Integer/parseInt s base)))
Note that assuming false and nil are both considered non-values, (if (nil? base) 10 base) could be shortened to (if base base 10), or further to (or base 10).