You can use the following regular expression to check if a string constitutes a valid base64 encoding:
^([A-Za-z0-9+/]{4})*([A-Za-z0-9+/]{3}=|[A-Za-z0-9+/]{2}==)?$
In base64 encoding, the character set is [A-Z, a-z, 0-9, and + /]. If the rest length is less than 4, the string is padded with '=' characters.
^([A-Za-z0-9+/]{4})* means the string starts with 0 or more base64 groups.
([A-Za-z0-9+/]{4}|[A-Za-z0-9+/]{3}=|[A-Za-z0-9+/]{2}==)$ means the string ends in one of three forms: [A-Za-z0-9+/]{4}, [A-Za-z0-9+/]{3}= or [A-Za-z0-9+/]{2}==.