How to change default layout in express using handlebars?

You can specify what layout you want to use as part of the render call. If you create a new layout called other.hbs, you can then do something like:

res.render('view', { title: 'my other page', layout: 'other' });

To override this for the entire application, you can use:

app.set('view options', { layout: 'other' });