How do I set a textbox’s text to bold at run time?

The bold property of the font itself is read only, but the actual font property of the text box is not. You can change the font of the textbox to bold as follows:

  textBox1.Font = new Font(textBox1.Font, FontStyle.Bold);

And then back again:

  textBox1.Font = new Font(textBox1.Font, FontStyle.Regular);