This answer complements Ankit Goel’s correct :quit answer to also (1) provide an understanding of why the : is needed and (2) other options besides :quit.
Swift REPL works in conjuction with the LLDB debugger.
: is a REPL escape prefix to execute an LLDB command. From within REPL, :help will list the available LLDB commands.
Any of the following will quit both Swift REPL and subsequently LLDB with a single command line.
:exit
:quit
:q
One can also exit REPL into LLDB with just : and, then later quit (or exit) using the LLDB command directly.
sh$ swift
Welcome…
1> print(18 + 4)
22
2> :
(lldb) print "hello"
(String) $R0 = "hello"
(lldb) quit
sh$
Addendum: The LLDB command c or continue can be used to return to the Swift REPL environment.