How do I mock a django signal handler?

Possibly a better idea is to mock out the functionality inside the signal handler rather than the handler itself. Using the OP’s code:

@receiver(post_save, sender=User, dispatch_uid='myfile.signal_handler_post_save_user')
def signal_handler_post_save_user(sender, *args, **kwargs):
  do_stuff()  # <-- mock this

def do_stuff():
   ... do stuff in here

Then mock do_stuff:

with mock.patch('myapp.myfile.do_stuff') as mocked_handler:
    self.assert_equal(mocked_handler.call_count, 1)