The cleanest way would be to use the mutable.Map varargs factory. Unlike the ++ approach, this uses the CanBuildFrom mechanism, and so has the potential to be more efficient if library code was written to take advantage of this:
val m = collection.immutable.Map(1->"one",2->"Two")
val n = collection.mutable.Map(m.toSeq: _*)
This works because a Map can also be viewed as a sequence of Pairs.