As long as you’re using IIS 7 or above, it’s as simple as adding it to your web.config.
<configuration>
<system.webServer>
<httpProtocol>
<customHeaders>
<add name="X-Content-Type-Options" value="nosniff" />
</customHeaders>
</httpProtocol>
</system.webServer>
</configuration>
Or you can add them using the IIS Management GUI, or even command line. Take a look at http://www.iis.net/configreference/system.webserver/httpprotocol/customheaders