How adding event handler inside a class with a class-method as the callback?

The this inside the event listener callback will be the element that fired the event. If you want the this to be the instance of your class, then either:

Bind the function to the class instance:

Using Function.prototype.bind, will create a new function that its this value will always be what you specify it to be (the class instance):

r.addEventListener('mouseover', this.OnEvent.bind(this));
//                                          ^^^^^^^^^^^

Wrap the function inside an anonymous function:

var that = this;
r.addEventListener('mouseover', function(ev) { that.OnEvent(ev); });
//                              ^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^

or use an arrow function (so no need for that):

r.addEventListener('mouseover', ev => this.OnEvent(ev));
//                              ^^^^^^^^^^^^^^^^^^^^^^

Note: As mentioned in a comment bellow, both of the above methods pass a different function to addEventListener (the one with bind create a new function, and the anounimous function is obviously !== this.OnEvent). If you are going to remove the event listener later, you’ll have to store a reference to the function:

var reference;
r.addEventListener('mouseover', reference = this.OnEvent.bind(this));
//                              ^^^^^^^^^^^^

or:

var reference;
var that = this;
r.addEventListener('mouseover', reference = function(ev) { that.OnEvent(ev); });
//                              ^^^^^^^^^^^^

then you can remove the event listener like:

r.removeEventListener('mouseover', reference);