You can use withLatestFrom.
.
source.withLatestFrom(checkboxes, (data, checkbox) => ({data, checkbox}))
.filter(({data, checkbox}) => ...)
Here, checkboxes is an observable representing a list of checkbox inputs. source is an observable representing a stream of events coming from the server. In the filter function you can check if the data is valid compared to the checkbox settings and let it trough.
Notice it is important checkboxes emits at least 1 value before the stream can emit anything.
Ps. In regard to other answers, this solution works even if the source is cold.