Just use a middleware statement that executes for all routes:
// a middleware with no mount path; gets executed for every request to the app
app.use(function(req, res, next) {
res.setHeader('charset', 'utf-8')
next();
});
And, make sure this is registered before any routes that you want it to apply to:
app.use(...);
app.get('/index.html', ...);
Express middleware documentation here.