Drop data frame columns by name

You can use a simple list of names :

DF <- data.frame(
  x=1:10,
  y=10:1,
  z=rep(5,10),
  a=11:20
)
drops <- c("x","z")
DF[ , !(names(DF) %in% drops)]

Or, alternatively, you can make a list of those to keep and refer to them by name :

keeps <- c("y", "a")
DF[keeps]

EDIT :
For those still not acquainted with the drop argument of the indexing function, if you want to keep one column as a data frame, you do:

keeps <- "y"
DF[ , keeps, drop = FALSE]

drop=TRUE (or not mentioning it) will drop unnecessary dimensions, and hence return a vector with the values of column y.